富田研究室は、生体工学と医学の専門家が集まって、実際の役に立つ医工学技術開発を行っています。

 

Achievements

研究業績は2003年以降の原著論文、解説を新着順に並べております。-> 原著論文 | 解説

原著論文

2017 | 2016 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003

2017

Kasai, N., H. Mera, S. Wakitani, Y. Morita, N. Tomita and M. Takagi
Effect of epigallocatechin-3-o-gallate and quercetin on the cryopreservation of cartilage tissue
Bioscience Biotechnology and Biochemistry 81(1): 197-199, (2017).

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2016

Hirakata, E., N. Tomita, Y. Tamada, T. Suguro, M. Nakajima, Y. Kambe, K. Yamada, K. Yamamoto, M. Kawakami, A. Otaka, H. Okumura and S. Suzuki
Early tissue formation on whole-area osteochondral defect of rabbit patella by covering with fibroin sponge
Journal of Biomedical Materials Research Part B-Applied Biomaterials 104(7): 1474-1482, (2016)

Kambe, Y., K. Kojima, Y. Tamada, N. Tomita and T. Kameda
Silk fibroin sponges with cell growth-promoting activity induced by genetically fused basic fibroblast growth factor
Journal of Biomedical Materials Research Part A 104(1): 82-93, (2016)

Kambe, Y., K. Kojima, N. Tomita, Y. Tamada and T. Yamaoka
Development of a FRET-based recombinant tension sensor to visualize cell-material interactions
Journal of Materials Chemistry B 4(4): 649-655, (2016).

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2014

Otaka, A., K. Takahashi, Y. S. Takeda, Y. Kambe, Y. Kuwana, Y. Tamada and N. Tomita
Quantification of Cell Co-Migration Occurrences During Cell Aggregation on Fibroin Substrates
Tissue Engineering Part C-Methods 20(8): 671-680, (2014).

Turner, A., Y. Okubo, S. Teramura, Y. Niwa, K. Ibaraki, T. Kawasaki, D. Hamada, K. Uetsuki and N. Tomita
The antioxidant and non-antioxidant contributions of vitamin E in vitamin E blended ultra-high molecular weight polyethylene for total knee replacement
Journal of the Mechanical Behavior of Biomedical Materials 31: 21-30, (2014).

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2013

Oe, K., S. Jingushi, H. Iida and N. Tomita
Evaluation of the clinical performance of ultrahigh molecular weight polyethylene fiber cable using a dog osteosynthesis model
Bio-Medical Materials and Engineering 23(5): 329-338, (2013).

Harada, Y., K. Kadono, T. Terao, M. Suzuki, Y. Ikada and N. Tomita
Helical Conformation Endows Poly-L-Lactic Acid Fibers with a Piezoelectric Charge under Tensile Stress
Journal of Veterinary Medical Science 75(9): 1187-1192, (2013).

Hashimoto, T., K. Kojima, A. Otaka, Y. S. Takeda, N. Tomita and Y. Tamada
Quantitative Evaluation of Fibroblast Migration on a Silk Fibroin Surface and TGFBI Gene Expression
Journal of Biomaterials Science-Polymer Edition 24(2): 158-169, (2013).

Otaka A., Takahashi K., Isshiki K, Kambe Y., Kojima K., Tamada Y, Tomita N.
How do chondrocytes aggregate on fibroin substrate
35th Annual International Conference of the IEEE EMBS, (2013).

Otaka A., Takahashi K., Takeda S. Y. Kambe Y., Kuwana Y.., Tamada Y, Tomita N.
Quantification of Cell Co-Migration Occurrences During Cell Aggregation on Fibroin Substrates
Tissue Engineering Part C: Methods, (2013).

Otaka A., Kachi D. N., Hatano N, Kuwana Y., Tamada Y., Tomita N.
Observation and Quantification of Chondrocyte Aggregation Behavior on Fibroin Surfaces Using Voronoi Partition
Tissue Engineering Part C: Methods, (2013).

Xu, S., H. Okano, M. Nakajima, N. Hatano, N. Tomita and Y. Ikada
Static magnetic field effects on impaired peripheral vasomotion in conscious rats
Evidence-based complementary and alternative medicine : eCAM, (2013).

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2012

Otaka A., Takahashi K., Isshiki K, Kambe Y., Kojima K., Tamada Y, Tomita N.
How do chondrocytes aggregate on fibroin substrate
35th Annual International Conference of the IEEE EMBS, (2012).

Otaka A., Takahashi K., Takeda S. Y. Kambe Y., Kuwana Y.., Tamada Y, Tomita N.
Quantification of Cell Co-Migration Occurrences During Cell Aggregation on Fibroin Substrates
Tissue Engineering Part C: Methods, (2012).

Turner A., Okubo Y., Teramura S., Niwa Y., Ibaraki K., Kawasaki T., Hamada D., Uetsuki K., Tomita N.
The antioxidant and non-antioxidant contributions of vitamin E in vitamin E blended ultra-high molecular weight polyethylene for total knee replacement
Journal of the Mechanical Behavior of Biomedical Materials, (2012).

Otaka A., Kachi D. N., Hatano N., Kuwana Y., Tamada Y., Tomita N.
Observation and quantification of chondrocyte aggregation behavior on fibroin surfaces using Voronoi Partition
Tissue Engineering Part C: Methods, (2012).

Hashimoto T., Kojima K., Otaka A., Takeda Y.S., Tomita N. and Tamada Y.
Quantitative evaluation of fibroblast migration on silk fibroin surface and TGFBI gene expression
Journal of Biomaterials Science: Polymer Edition, (2012).

Kambe Y., Hayashi N., and Tomita N.
Adhesive force behavior of single ATDC5 cells in chondrogenic culture
Biochemical and Biophysical Research Communications, 420 (2012), pp. 241-246.

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2011

Kawakami M., Tomita N., Shimada Y., Yamamoto K., Tamada Y., Kachi N. and Suguro T.
Chondrocyte Distribution and Cartilage Regeneration in Silk Fibroin Sponge
Bio-Medical Materials and Engineering, 21(1), (2011), 53-61.

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2010

Kambe Y., Takeda Y., Yamamoto K., Kojima K., Tamada Y. and Tomita N.
Effect of RGDS-Expressing Fibroin Dose on Initial Adhesive Force of a Single Chondrocyte
Bio-Medical Materials and Engineering, 20(6), (2010), 309-316.

Yamada K., Oda K. and Tomita N.
Measurement of Probe Angle for Ultrasound Evaluation of Articular Cartilage Using Rise-to-Peak Time
Journal of Biomechanical Science and Engineering, 5(5) (2010), 615-624.

Kambe Y., Yamamoto K., Kojima K., Tamada Y. and Tomita N.
Effects of RGDS Sequence Genetically Interfused in the Silk Fibroin Light Chain Protein on Chondrocyte Adhesion and Cartilage Synthesis
Biomaterials, 31(29) (2010), 7503-7511.

Kachi D.N., Otaka A., Sim S., Kuwana Y., Tamada Y., Sunaga J., Adachi T. and Tomita N.
Observation of Chondrocyte Aggregate Formation and Internal Structure on Micropatterned Fibroin-Coated Surface
Bio-Medical Materials and Engineering, 20(1) (2010), 55-63.

Okubo Y., Hamada D., Yamamoto K., Mori S., Ikeuchi K. and Tomita N.
Load-Dependent Frictional Performance of Vitamin E-Blended Ultrahigh Molecular Weight Polyethylene in Serum Lubricant
Tribology Online, 5(2) (2010), 96-101.

Yamada K., Ikeuchi K., Hattori K. and Tomita N.
Correction of Thickness Measurement by Ultrasound for Articular Cartilage Using Sound Velocity Estimation
Journal of Biomechanical Science and Engineering, 5(2) (2010), 175-184.

Okubo Y., Mori S., Yamamoto K. and Tomita N.
Confirmation of Pressure-Induced Leaching of Vitamin E from inside of Ultrahigh Molecular Weight Polyethylene
Journal of Biomechanical Science and Engineering, 5(2) (2010), 154-162.

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2009

Okubo Y., Teramura S., Niwa Y., Ibaraki K., Murata K., Hyon S.H., Pezzotti G. and Tomita N.
Strain-Induced Crystallization and Orientation of Vitamin E-Blended Ultrahigh Molecular Weight Polyethylene
Bio-Medical Materials and Engineering, 19(6) (2009), 431-439.

Teramura S., Sakoda H., Terao T., Fujiwara K., Kawai K. and Tomita N.
Reduction of Wear Volume from Accelerated Aged UHMWPE Knee Components by the Addition of Vitamin E
Journal of Biomechanical Science and Engineering, 4(4) (2009), 589-596.

Okubo Y., Mori S., Yamamoto K., Hamada D., Kohno H., Fujiwara K., Hashimoto M., Ikeuchi K. and Tomita N.
Mechanical Interaction between Vitamin E-Containing Ultrahigh Molecular Weight Polyethylene and Co-28Cr-6Mo Alloy in Water
Journal of Biomechanical Science and Engineering, 4(2) (2009), 166-173.

Kachi N., Tomita N., Yamamoto K., Takaya R. and Tamada Y.
Tribological Maturation of Regenerated Cartilage was Inhibited by Using Chondrocyte Aggregates
Journal of Biomechanical Science and Engineering, 4(2) (2009), 174-181.

神戸裕介, 山本浩司, 小島桂, 玉田靖, 富田直秀
RGDSトランスジェニックフィブロイン基質に対する軟骨細胞の接着性と組織形成
臨床バイオメカニクス, 30 (2009), 71-75.

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2008

Nakajima M., Wakitani S., Harada Y., Tanigami A. and Tomita N.
In Vivo Mechanical Condition Plays an Important Role for Appearance of Cartilage Tissue in ES Cell Transplanted Joint
Journal of Orthopaedic Research, 26 (2008), 10-17.

Teramura S., Sakoda H., Terao T., Endo M.M., Fujiwara K. and Tomita N.
Reduction of Wear Volume from Ultrahigh Molecular Weight Polyethylene Knee Components by the Addition of Vitamin E
Jounal of Orthopaedic Research , 4 (2008), 460-464.

Yamamoto K., Takaya R., Tamada Y. and Tomita N.
Effects of Tribological Loading History on the Expression of Tribological Function of Regenerated Cartilage
Tribology Online, 3(2) (2008), 148-152.

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2007

Yamamoto K., Tomita N., Fukuda Y., Suzuki S., Igarashi N., Suguro T. and Tamada Y.
Time-Dependent Changes in Adhesive Force between Chondrocytes and Silk Fibroin Substrate
Biomaterials, 28 (2007), 1838-1846.

Chueh S., Tomita N., Yamamoto K., Harada Y., Nakajima M., Terao T. and Tamada Y.
Transplantation of Allogenic Chondrocytes Cultured in Fibroin Sponge and Stirring Chamber to Promote Cartilage Regeneration
Tissue Engineering, 13 (2007), 483-492.

Chueh S., Tachibana Y., Uyama H., Kobayashi S. and Tomita N.
Evaluation of Chondrocytes Expression Embedded in Thermoresponsive Poly(amino acid)s with Sol-Gel Transition
Bio-medical Materials and Engineering, 17 (2007), 137-146.

Chueh S., Tomita N., Ikeuchi K. and Ikada Y.
Recovery of Small-Sized Blood Vessels in Ischemic Bone under Static Magnetic Field
Evidence-based Complementary and Alternative Medicine (eCAM), 4(1) (2007), 59-63.

Okano H., Tomita N. and Ikada Y.
Effects of 120 mT Static Magnetic Field on TGF-β1-Inhibited Endothelial Tubular Formation In Vitro
Bioelectromagnetics, 28 (2007), 497-499.

原田恭治, 中山正成, 田中宏, 富田直秀, 原康, 根津欣典, 余戸拓也, 多川政弘
骨癒合遅延症例に対する自家骨髄由来間葉系間質細胞を用いた治療法の試み
獣医麻酔外科誌, 37 (2007), 79-84.

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2006

Okano H., Onmori R., Tomita N. and Ikada Y.
Effects of a moderate-intensity static magnetic field on VEGF-A stimulated endothelial capillary tubule formation in vitro
Bioelectromagnetics, 27 (2006), 628-640.

可知直芳,富田直秀
細胞凝集体の作成とその機能評価
日本臨床バイオメカニクス学会誌, 27 (2006), 83-88.

寺村聡,世宮俊輔,山本浩司,波田野直也,富田直秀
遠心力を利用した物理環境が初期接着細胞に及ぼす影響
日本臨床バイオメカニクス学会誌, 27 (2006), 67-70.

Seto Y., Tomita N., Harada Y., Sakoda H. and Takakura Y.
Regenerated Soft Tissue Survival Using Repulsive Force of Magnetized Devices: Preliminary Report
Journal of Orthopedic Science, 11 (2006), 58-63.

Morita Y., Tomita N., Aoki H., Sonobe M., Wakitani S., Tamada Y., Suguro T. and Ikeuchi K.
Frictional Propertics of Regend Cartilage in Vitro
Journal of Biomechanics, 39(1) (2006), 103-109.

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2005

Hattori K., Yoshikawa T., Takakura Y., Aoki H., Sonobe M. and Tomita N.
Bio-Artifical Periosteum for Severe Open Fracture-An Experimental Study of Osteogenic Cell / Collagen Sponge Composite as a Bio-Artificial Periosteum
Bio-Medical Materials and Engineering, 15(3) (2005),127-136.

Sonobe M., Hattori K., Tomita N., Yoshikawa T., Aoki H., Takakura Y. and Suguro T.
Stimulatpry Effects of Stations on Bone Marrow-Derived Mesenchymal Stem Cells. Study of a New Therapeutic Agent for Fracture
Bio-Medical Materials and Engineering,15(4) (2005), 261-267.

Tomihata K., Suzuki M. and Tomita N.
Handling Characteristics of Poly(L-lactide-co-ε-caprolactone) Monofilament Suture
Bio-Medical Materials and Engineering, 15 (2005), 381-391.

Harada Y., Tomita N., Nakajima M.,Ikeuchi K. and Wakitani S.
Effect of Low Loading and Joint Immobilization For Spontaneous Repair of Osteochondral Defect in the Knees of Weightless (tail suspension) Rats
Journal of Orthopedic Science, 10 (2005), 508-514.

闕上凱,原田恭治,富田直秀
Effect of sliding mechanical force on regenerated cartilage tissue construct in vitro
日本臨床バイオメカニクス学会誌, 26 (2005), 297-303.

山本浩司,門林義幸,中嶋正明,富田直秀
生体環境設計のための状態還移モデルの作製
日本臨床バイオメカニクス学会誌, 26 (2005), 291-296.

寺村聡,富田直秀,原田恭治,闕上凱,前北渉,安達泰治,鈴木基史
ナノスケールで表面形状を制御した材料上における細胞培養
日本臨床バイオメカニクス学会誌, 26 (2005), 227-232.

山本浩司,甲斐元崇,玉島康優,園部正人,森田有亮,池内健,小泉孝之,辻内伸好,玉田靖,富田直秀
再生軟骨の摩擦・摩耗特性
日本臨床バイオメカニクス学会誌, 26 (2005), 97-102.

柴田延幸,富田直秀
再生用scaffold−軟骨細胞系ミクロ有限要素モデルの構築
日本臨床バイオメカニクス学会誌, 26 (2005), 19-25.

Shibata N. and Tomita N.
The Anti-Oxidative Properties of α-Tocopherol in γ-Irradiated UHMWPE with Respect to Fatigue and Oxidation Resistance
Biomaterials, 26 (2005), 5755-5762.

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2004

Yamamoto K., Yamaguchi M., Tani M., Hangyo M., Teramura S., Isu T. and Tomita N.
Degradation Deagnosis of Ultrahigh-Molecular Weight Polyethylene with Terahertz-Time-Domain Spectroscopy
Applied Physics Letters, 85(22) (2004), 5194-5196.

柴田延幸,富田直秀
ビタミンEの抗酸化作用がデラミネーションを含むUHMWPEの疲労特性の向上に及ぼす影響
日本臨床バイオメカニクス学会誌, 25 (2004), 357-362.

丹羽康仁,山田修一,柴田延幸,倪慶清,増田稔,村田功二,寺村聡,小林広樹,富田直秀
人工膝関節用超高分子量ポリエチレンの微小領域変形挙動に関する研究
日本臨床バイオメカニクス学会誌, 25 (2004), 363-368.

小林正和,山下進介,西脇眞二,泉井一浩,吉村允孝,富田直秀
トポロジー最適化と形状最適化に基づいたコンプライアントメカニズムの多段階創成設計法
精密工学会誌, 70(11) (2004), 1455-1460.

寺村聡,富田直秀,河島俊一郎,藤田和久,青木正彦,井須俊郎
人工膝関節用Vitamin E添加超高分子量ポリエチレンの耐酸化性
表面科学, 25(9) (2004), 568-572.

Wakitani S., Aoki H., Harada Y., Sonobe M., Morita Y., Mu Y., Tomita N., Nakamura Y., Takeda S., Takeshi K., Watanabe K. and Tanigami A.
Embryonic Stem Cells Form Articular Cartilage, not Teratomas, in Osteochondral Defects of Rat Joints
Cell Transplantation, 13 (2004), 331-336.

富田直秀
人工膝関節の工学デザインの限界と可動性
関節外科, 23(7) (2004), 17-22.

富田直秀
生体材料と生体内環境設計 (Bio-Environment Designing for Biomaterials)
材料, 53(1) (2004), 91-94.

Ohata R., Tomita N. and Ikada Y.
Effect of a Static Magnetic Field on Ion Transport in a Cellulose Membrane
Journal of Colloid and Interface Science, 270 (2004), 413-416.

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2003

Aoki H., Tomita N., Harada Y., Hattori K., Sonobe M. and Suguro T.
The Report of the Cartilage Regeneration Using Total Joint Regeneration System (Internal-fixator type)
Bio-Medical Materials and Engineering, 13(4) (2003), 411-417.

Morita Y., Tomita N., Aoki H., Wakitani S., Tamada Y., Suguro T. and Ikeuchi K.
Evaluation of Dynamic visco-Elastic Properties During Cartilage Regenerating Process in Vitro
Bio-Medical Materials and Engineering, 13(4) (2003), 345-353.

Aoki H., Tomia N., Morita Y., Hattori K., Harada Y., Sonobe M., Wakitani S. and Tamada Y.
Culture of Chondrocytes in Fibroin-Hydrogel Sponge
Bio-Medical Materials and Engineering, 13(4) (2003), 309-316.

Shibata N., Tomita N. and Ikeuchi K.
Numerical Simulations on Fatigue Destruction of Ultra-high Molecular Weight Polyethylene Using Discrete Element Analyses
Journal of Biomedical Materials Research Part A, 64A(3) (2003), 570-582.

森田有亮,富田直秀,青木秀之,園部正人,脇谷滋之,玉田靖,勝呂徹,池内健
再生軟骨の潤滑特性
日本臨床バイオメカニクス学会誌, 24 (2003), 53-58.

園部正人,富田直秀,青木秀之,原田恭治,森田有亮,池内 健,服部耕治,玉田靖,脇谷滋之,勝呂徹
硫酸化フィブロインスポンジを用いた軟骨再生の試み
日本臨床バイオメカニクス学会誌, 24 (2003), 45-51.

Shibata N., Tomita N., Onmori N., Kato K. and Ikeuchi K.
Defect Initiation at Subsurface Grain Boundary as a Precursor of Delamination in Ultrahigh Molecular Weight Polyethylene
Journal of Biomedical Materials Research Part A, 67A(1) (2003), 276-284.

森亜希子,富田直秀,金枝敏明,渡辺英一郎,永田員也,尾坂明義,藏本孝一
ビタミンE添加UHMWPE材料の疲労特性 -人工膝関節におけるlift-offを考慮して
生体材料, 21(5) (2003), 403-409.

園部正人,青木秀之,勝呂徹,服部耕治,吉川隆章,高倉義典,富田直秀
骨髄間質細胞に対するフルバスタチンの骨形成促進効果
骨折, 25(1) (2003), 57-60.

Shibata N., Tomita N. and Ikeuchi K.
Microscopic Destruction of Ultra-High Molecular Weight Polyethylene(UHMWPE) Under Uniaxial Tension
Bio-Medical Material and Engineering,13 (2003), 47-57.

Shibata N., Tomita N. and Ikeuchi K.
Gamma-Irradiation Aggravates Stress Concentration Along Subsurface Grain Boundary of Ultra-High Molecular Weight Polyethylene(UHMWPE) Under Sliding Fatigue Environment
Bio-Medical Materials and Engineering, 13 (2003), 35-45.

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解説

2017

富田直秀
人工臓器 最近の進歩 バイオメカニクス 構造的アプローチから広義の構成論的アプローチへ
人工臓器 46(3): 176-179.(2017).

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2016

富田直秀
【バイオメカニクスから考えるスポーツ医科学】 スポーツ外傷・障害のバイオメカニクス テニス肘発症メカニズム 直接計測と構成的臨床工学
臨床スポーツ医学 33(1): 58-63.(2016).

2015

富田直秀
人工臓器 最近の進歩 再生医療技術の文化としての進歩
人工臓器 44(3): 186-189.(2015).

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2014

富田直秀
医療機器 薬事業務のトラの穴(第6回) 何が無駄で何が真に有効なのか 「質」で選別される医療技術とデザイン実践
PHARM TECH JAPAN 30(7): 1275-1279.(2014).

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2013

富田直秀
【股関節をめぐる最新の進歩】 (Part1)股関節の基礎的研究 ビタミンE(dl-α-tocopherol)混合ポリエチレン
Bone Joint Nerve 3(3): 425-433.(2013).

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2007

富田直秀
人工膝関節用ビタミンE添加超高分子量ポリエチレンーProblem Orientの15年間ー
高分子, 56(9) (2006), 763.

富田直秀
医療材料としてのシルク利用
BIO INDUSTRY, 24(11) (2006), 19-26.

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2006

Shibata N., Kurtz M S. and Tomita N.
Recent Advances of Mechanical Performance and Oxidation Stability in Ultrahigh Molecular Weight Polyethylene for Total Joint Replacement: Highly Crosslinked and α-Tocopherol Doped
Jounal of Biomechanical Science and Engineering, 1(1) (2006), 107-123.

富田直秀 他
第6版 科学便覧 応用化学編 (2006).

富田直秀
バイオエンジニアリングの基礎V(生体の多様性に働きかける材料)
Diamond,80号,22(1) (2006), 53-56.

富田直秀
再生医療における医工連携(医と工の立場から)
日本機械学会誌, 109(1047) (2006), 30-31.

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2005

富田直秀
バイオエンジニアリングの基礎U(生体材料設計と生体環境設計)
New Diamond, 79号,21(4) (2005), 47-50.

富田直秀
バイオエンジニアリングの基礎 (1)生体機能解釈のパラダイムシフト
NEW DIAMOND, 21(3) (2005), 38-41.

富田直秀
生体吸収性材料の実用化と生体環境設計
生物工学会誌, 83(5) (2005), 227-229.

富田直秀
人工関節と関節治療
人工臓器, 33(3) (2005), 215-218.

富田直秀
環境設計の考え方とその応用
臨床リウマチ, 17(1) (2005), 9月15日.

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2004

富田直秀
生体内環境設計(方法論としてのオートポイエティック・マシン)
骨・関節・靱帯, 17(3) (2004), 269-274.

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2003

富田直秀
不良学者から不良学生たちへ
BME, 17(1) (2003), 59-62.

富田直秀
最近の生体材料設計に関して
NEW DIAMOND, 19(2) (2003), 5月8日.

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京都大学 工学研究科 機械理工学専攻 医療工学分野(医学研究科 生体工学分野)
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工学研究科 富田研究室(b2N01)
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